منابع مشابه
NESH Regulates Dendritic Spine Morphology and Synapse Formation
BACKGROUND Dendritic spines are small membranous protrusions on the neuronal dendrites that receive synaptic input from axon terminals. Despite their importance for integrating the enormous information flow in the brain, the molecular mechanisms regulating spine morphogenesis are not well understood. NESH/Abi-3 is a member of the Abl interactor (Abi) protein family, and its overexpression is kn...
متن کاملF-Actin-Dependent Regulation of NESH Dynamics in Rat Hippocampal Neurons
Synaptic plasticity is an important feature of neurons essential for learning and memory. Postsynaptic organization and composition are dynamically remodeled in response to diverse synaptic inputs during synaptic plasticity. During this process, the dynamics and localization of postsynaptic proteins are also precisely regulated. NESH/Abi-3 is a member of the Abl interactor (Abi) protein family....
متن کاملForced expression of NESH suppresses motility and metastatic dissemination of malignant cells.
To characterize the function of a novel Src homology 3 (SH3) adapter protein termed NESH, we have established transfectants stably expressing NESH. We observed that every clone of NESH transfectants caused a marked reduction in motility, although the clones exhibited no significant differences in intrinsic cell growth compared with the control cells in vitro. The NESH transfectants also exhibit...
متن کاملInsulin receptor substrate protein 53 (IRSp53) as a binding partner of antimetastasis molecule NESH, a member of Abelson interactor protein family.
Involvement of NESH in cancer invasion and metastasis is now very important and interesting. In order to clarify the molecular mechanisms, we identified insulin receptor substrate protein 53 (IRSp53) as a partner of NESH utilizing a conventional yeast two-hybrid screen with a proline-rich domain of NESH as bait. The specific interaction was confirmed by coimmunoprecipitation assay and colocaliz...
متن کاملInsulin receptor substrate protein 53 (IRSp53) as a binding partner of antimetastasis molecule NESH, a member of Abelson interactor protein family Involvement of NESH in cancer invasion and metastasis
Involvement of NESH in cancer invasion and metastasis is now very important and interesting. In order to clarify the molecular mechanisms, we identified insulin receptor substrate protein 53 (IRSp53) as a partner of NESH utilizing a conventional yeast two-hybrid screen with a proline-rich domain of NESH as bait. The specific interaction was confirmed by coimmunoprecipitation assay and colocaliz...
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ژورنال
عنوان ژورنال: Ondokuz Mayıs Üniversitesi İlahiyat Fakültesi Dergisi
سال: 2018
ISSN: 2587-1854
DOI: 10.17120/omuifd.459182